Scientific Programme

The conference consisted of plenary lectures, as well as opportunities to network and hold informal discussions among participants. The interdisciplinary conference included speakers from a wide variety of fields, who added value to the discussions.

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DAY ONE Tuesday 4 September

12:00-13:40 Henriette Raphael Building, Main Function Room

Registration, Lunch and Networking

13:40-13:55 Lecture Theatre 2

Introduction and Greetings

1. Greetings from Professor Reza Razavi, VP for Research and Innovation at King’s College, London

2. Greetings from Ambassador David Quarrey

3. Greetings from a member from the UK-Israel Science Council Chairs

13:55-14:40 Lecture Theatre 2 

Keynote Speaker: Janet Lord, University of Birmingham
Immunesenescence and its contribution to the ageing phenotype

14:45-17:10 Lecture Theatre 2

Session I, Inflammation

Chairs: Doron Melamed and Rhian Touyz

14:45-15:10 – Rhian Touyz, University of Glasgow
Vascular ageing at the heart of chronic disease

15:10-15:30 – Shai Shen-Orr, Technion – Israel Institute of Technology
High Resolution Longitudinal Immune Profiling Reveals the Dynamics of Healthy Immune-Ageingand it’s Relation to Cardiovascular Risk

15:30-15:50 – Ann McArdle, University of Liverpool
Musculoskeletal ageing

15:50-16:10 – Doron Melamed, Technion – Israel Institute of Technology
B cell hematopoiesis in aging under endocrine control

16:10-16:30 – Justin Mason, Imperial College London
Vascular cytoprotection, autoimmune disease and premature atherosclerosis

16:30-16:50 – Gregory Livshits, Tel Aviv University
Genetics of age-dependent frailty: from quantitive genetics to omics technologies

16:50-17:10 – Noga Ron-Harel, Technion – Israel Institute of Technology
Defective metabolic reprogramming contributes to impaired naive T cell function in aged mice

17:10-17:25 New Hunts House, G.4 and Lobby

Refreshment Break and Networking

17:25-18:05 Lecture Theatre 2

Young Researchers “Quick Fire” Session

17:25-17:30 – Liam Cassidy, University of Cambridge
Genetic inhibition and restoration of autophagy uncovers incomplete reversal of ageing phenotypes 

17:3-17:35 – Danielle Gutman, University of Haifa 
The centenarian epigenome – an enigmatic environmental-genome crosstalk underlying longevity mechanism  

17:35-17:40 – Juliana de Almeida Faria, University of Cambridge 
miR-126 Regulates Adipocyte ER Stress and Glucose Homeostasis Through Lunapark and IRS-1

17:40-17:45 – Asael Roichman, Bar-Ilan University 
SIRT6 controls energy metabolism to regulate lifespan and healthspan 

17:45-17:50 – Ruth Musgrove, The Hebrew University of Jerusalem
Neuronal vulnerability in the dorsal motor nucleus of the vagus nerve: Combined effects of alpha-synuclein and oxidative stress 

17:50-17:55 – Noa Chapal IIani and Nathali Kaushansky, Weizmann Institute of Science
Long Term AML Survivors Have Increased Mortality and High Prevalence of Clonal Hematopoiesis 

17:55-18:00 – James Cole, King’s College London
Brain-age predicts disability in multiple sclerosis

18:00-18:05 – Irundika Dias, Aston University 
Mass spectrometry based profiling of PUFA-derived lipid oxidation products

18:05-20:00 Main Function Room and Revelstoke Room, Henriette Raphael Building

Poster Presentation and Networking Event

Drinks and Canapes provided.

DAY Two Wednesday 5 September

07:00-08:00 Restaurant, Henriette Raphael Building

Breakfast and Networking

Parallel Sessions

08:00-10:20 Lecture Theatre 1

Session II, Neurodegeneration

08:00-08:20 – Rebecca Taylor, University of Cambridge
The Neuronal Regulation of Ageing Through Stress Response Activation

08:20-08:40 – Eitan Okun, Bar-Ilan University
Vaccination strategies for Age-related neurodegenerative disorders

08:40-09:00 – Chris Shaw, King’s College London
Moving from genetic diagnosis to precision therapy in ALS and FTD

09:00-09:20 – Pablo Blinder, Tel-Aviv University
Neurovascular coupling

09:20-09:40 – Ehud Cohen, The Hebrew University of Jerusalem
The manipulation of ageing as a novel approach for the treatment of neurodegenerative disorders

09:40-10:00 – Simone Engelender, Technion – Israel Institute of Technology
Ubiquitination and SUMOylation in Parkinson’s disease

10:00-10:20 – Ruth Gabizon, Hadassah University Hospital
The role of oxidative stress and antioxidants in neurodegenerative diseases

08:00-10:20 Lecture Theatre 2

Session III, General Ageing

08:00-08:20 – Tomas Guzik, University of Glasgow
The immunology of hypertension

08:20-08:40 – Anat Ben-Zvi, Ben-Gurion University
Remolding of protesostasis in ageing

08:40-09:00 – Rebecca Reynolds, University Edinburgh
Maternal obesity in pregnancy and the legacy for the offspring

09:00-09:20 – Gil Atzmon, University of Haifa
Longevity epignenetics

09:20-09:40 – Justin Mason, Imperial College London
Vascular cytoprotection, autoimmune disease and premature atherosclerosis

09:40-10:00 – Yuval Dor, The Hebrew University of Jerusalem
Non-invasive detection of cell death using methylation patterns of circulating DNA

10:00-10:20 – Sivan Kornblit, Bar-Ilan University
Maintaing proteostasis in the old – lessons from long-live mutants



10:20-10:35 New Hunt’s House, G.4 and Lobby

Coffee and Networking

10:40-11:25 Lecture Theatre 1

Keynote Speaker: Haim Cohen, Bar-IIan University
The regulation of healthy lifespan by SIRT6

Chair: Richard Siow, King’s College London

Parallel Sessions

11:30-13:30 Lecture Theatre 1

Session IV, Neurodegeneration

11:30-11:50 –Paul Dobson, University of Bristol
Disruption of dopamine neuron signalling by Lewy-body-like aggregates

11:50-12:10 – Josh Goldberg, The Hebrew University of Jerusalem
Neuroprotective responses to alpha-synuclein overexpression in neurons at risk in prodromal parkinsonism

12:10-12:30 – Sandrine Thuret, King’s College London
Hippocampal progenitor cells as biomarkers of cognitive ageing and dementia

12:30-12:50 – Eran Perlson, Tel-Aviv University
ALS as a spatiotemporal mislocalisation disease

12:50-13:10 – Alessio Vagnoni, King’s College London
Intracellular trafficking and neuronal ageing

13:10-13:30 – Hermona Soreq, Hebrew University of Jerusalem
Short non-coding whole blood RNAs from ischemic stroke patients reflect a circadian-dependent context

11:30-13:30 Lecture Theatre 2

Session V, Oxidative Stress

11:30-11:50 – Ralf Paus, The University of Manchester
Human scalp hair follicles as supreme ageing research model

11:50-12:10 – Ron Kohen, Hebrew University of Jerusalem
Stress defence mechanisms in aging skin; The role of the Nrf2-keap1 pathway and its unique activators

12:10-12:30 – Richard Siow, King’s College London
Vascular effects of the anti-ageing hormone klotho

12:30-12:50 – Moran Benhar, Technion – Israel Institute of Technology
Exploring the role of cysteine modifications in cellular redox signalling

12:50-13:10 – Helen Griffiths, University of Surrey
Lipid Oxidation in dementia

13:10-13:30 – Philippa Melamed, Technion – Israel Institute of Technology 
Reproductive Ageing in Health and Disease 

13:30-14:30 Revelstoke Room, Henriette Raphael Building

Lunch and Networking

Main Function Room,Henriette Raphael Building

Poster Viewing and Networking

14:35-16:35 Lecture Theatre 1

Session VI, General Ageing

Chairs: Nabieh Ayoub and Riccardo Marioni

14:35 – 14:55 – Axel Behrens, The Francis Crick Institute
Cancer Stem Cells

14:55-15:15 – Sheera Adar, Hebrew University of Jerusalem
DNA damage and repair in the chromatin context

15:15-15:35 – Riccardo Marioni, University of Edinburgh
Epigenetic prediction of age and modifiable lifestyle factors

15:15-15:35 – Itamar Harel, Hebrew University of Jerusalem
Exploring the genetics of aging using a naturally short-lived vertebrate

15:35-15:55 – John Mercer, University of Glasgow
Role of DNA damage and Mitochondrial Dysfunction in the Cardiovascular disease – Atherosclerosis

16:15-16:35 – Nabieh Ayub, Technion – Israel Institute of Technology
Transcriptional Modulation During DNA Damage Response

16:35-16:50 Lobby – New Hunts House

Coffee Break and Networking

16:55-17:40 Lecture Theatre 1

Keynote speaker: Andrew Baker, University of Edinburgh
Remodelling of the vasculature in cardiovascular Disease

17:40-18:25 Lecture Theatre 1

Young Researchers “Quick Fire” Session

Chair: Eran Perlson, Tel Aviv University 

17:40-17:45 – Thomas Francis, King’s College London
Identification and characterisation of the senescent phenotype of human primary myogenic precursor cells 

17:45-17:50 – Narmen Azameh, The Hebrew University of Jerusalem
Chronic expression of the tumor-supressor p16INK4a promotes early epidermal tumorigensis through Wnt-pathway activation

17:50-17:55 – Ran Salach Sopher, School of Mechanical Engineering Israel, Tel Aviv University 
The anatomy of the infrapatellar fat pad and it’s deformation during knee motion – as measured through dissection and MR imaging 

17:55-18:00 – Gwendoline Astre, The Hebrew University of Jerusalem
Targeting adipocyte haptoglobin during aging: a new insight to promote healthy aging
18:05-18:10 – Daniel Brayson, King’s College London
Prelamin A toxicity drives myocardial inflammaging in cardiomyopathies

18:10-18:15 – Naama Levi, Weizmann Institute of Science 
p53-dependent senescence in bronchial club cells promotes chronic lung inflammation

18:15-18:20 – Euan Owen, University of Liverpool 
Muscle as a source of inflammatory cytokines during ageing

18:20-18:25 – Chiara de Lucia, King’s College London
Nutrient-sensing pathways in Ageing Models of Hippocampal Progenitor Cell

18:25-19:50 Main Function Room, Henriette Raphael Building

Poster Viewing and Networking

20:00-22:00 Hop Exchange – Get Together Event 

Drinks Reception and Light Dinner provided.

DAY Three Thursday 6 September

07:00-08:20 Restaurant, Henriette Raphael Building

Breakfast and Networking

08:25-10:25 Lecture Theatre 1

Session VII, Nutrition and Exercise

Chairs: Gil Atzmon and Stephen Harridge 

08:25-08:45 –Malcolm Jackson, University of Liverpool
Localdenervation as a determinant of skeletal muscle redox status and degeneration during ageing

08:45-09:05 –Aron Troen, Hebrew University of Jerusalem
Neuroprotective Nutritional Interventions

09:05-09:25 –Stephen Harridge, King’s College London
Muscle, exercise and ageing

09:25-09:45 –Omry Koren, Bar-Ilan University
The gut microbiome in health and disease

09:45-10:05 –Illaria Bellantuono, University of Sheffield
Geroprotectors: a new approach for frailty and multimorbidity?

10:05-10:25 –Einav Gross, Hebrew University of Jerusalem
Mechanisms of aging in the nematode C. elegans

10:25-11:10 Lecture Theatre 1

Keynote speaker: Michal Schwartz, The Weizmann institute of Science
Harnessing the immune system to combat Alzheimer’s disease and age-related dementia

Chairs: Malcolm Jackson, University of Liverpool

11:10-11:25 New Hunt’s House, G.4 and Lobby

Coffee and Networking

Main Function Room, Henriette Raphael Building

Poster Viewing and Networking

11:25-13:05 Lecture Theatre 1

Session VIII, Cardiovascular & Endocrine

Chairs: Catherine Shanahan and Tamar Rubinek 

11:25-11:45 – Dominic Withers, Imperial College London

11:45-12:05 – Eli Keshet, The Hebrew University of Jerusalem
Lifespan and healthspan extension by vascular manipulations

12:05-12:25 – Catherine Shanahan, King’s College London
Mechanisms of Vascular Ageing

12:25-12:45 – Stefan Bornstein, King’s College London       
New Strategies in Islet Transplantation       

12:45-13:05 – Tamar Rubinek, Tel-Aviv Sourasky Medical Centre
The longevity hormone klotho: its role as a tumor suppressor

13:05-13:20 Lecture Theatre 1
Closing Remarks
Chairs and Scientific Committee Members: Haim Cohen and Richard Siow
13:20-14:35 Revelstoke Room, Henriette Raphael Building

Lunch and Networking


We are pleased to announce our partnership with Elsevier’s Journal, Experimental Gerontology and who will have Special Issue dedicated to our meeting. Speakers and early career researchers presenting at the conference will be invited to submit abstracts, original research and reviews. The Special Issue will be published early 2019 and there will be more details to follow.

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